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Does Ampreloxetine Help People with Symptomatic Neurogenic Orthostatic Hypotension Feel Better?

A Phase 2 Study to Investigate Ampreloxetine in the Treatment of Symptomatic Neurogenic Orthostatic Hypotension (nOH)


  • Researchers wanted to learn if an investigational medication (ampreloxetine) could help adults diagnosed with symptomatic neurogenic orthostatic hypotension (symptomatic nOH)
  • When people living with symptomatic nOH stand, or sit up quickly, they may experience symptoms such as lightheadedness, dizziness, or the feeling that they are about to black out
  • The purpose of this study was to learn whether ampreloxetine is able to improve blood pressure and lessen symptoms in people living with symptomatic nOH, and to assess its safety and tolerability
  • Ampreloxetine is not currently approved

What is symptomatic nOH?

  • In symptomatic nOH, the nerves that control blood pressure do not work adequately
  • When people with symptomatic nOH sit up or stand up, blood pressure falls, with symptoms of dizziness, lightheadedness, and feeling faint
  • Symptomatic nOH occurs in people with multiple system atrophy, Parkinson’s disease, and pure autonomic failure

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