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Peer Reviewed Articles

All of the below articles have recognized the support of the MSA Coalition.




(2020 –2022)

  1. 2022 Jan: Mavroeidi, Panagiota et al. “Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models.” Autophagy, 1-30. 9 Jan. 2022, MSA Coalition Grant #2020-05-001 (Xilouri) PATHOGENESIS

  2. 2021 Sep : Shukla, Jay J et al. “Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy.” Neurobiology of disease, vol. 159 105509. 16 Sep. 2021, MSA Coalition Grant #2017-10-009 (Finkelstein) PRECLINICAL
  3. 2021 Aug : Bettencourt, Conceição et al. “MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.” Neuropathology and applied neurobiology 47,5 (2021): 640-652. MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS

  4. 2021 Jul : Murthy, Megha et al. “Neurodegenerative movement disorders: An epigenetics perspective and promise for the future.” Neuropathology and applied neurobiology, 10.1111/nan.12757. 27 Jul. 2021, MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS

  5. 2021 Jun : Folke, Jonas et al. “Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson’s disease.” Parkinsonism & related disorders 87 (2021): 98-104. MSA Coalition Grant #2017-10-008 (Pakkenberg) PATHOGENESIS
  6. 2021 May : Mavroeidi, Panagiota, and Maria Xilouri. “Neurons and Glia Interplay in α-Synucleinopathies.” International journal of molecular sciences 22,9 4994. 8 May. 2021, MSA Coalition Grant #2020-05-001 (Xilouri) PATHOGENESIS

  7. 2021 May : Sidoroff, Victoria et al. “Characterization of gait variability in multiple system atrophy and Parkinson’s disease.” Journal of neurology, 268,5 (2021): 1770-1779. MSA Coalition Grant #2016-09-008 (Wenning) BIOMARKER
  8. 2021 May : Calandra-Buonaura, Giovanna et al. “Dysphagia in multiple system atrophy consensus statement on diagnosis, prognosis and treatment.” Parkinsonism & related disorders 86 (2021): 124-132. MSA Coalition Participated at the 2017 Consensus Conference in Bologna, Italy.

  9. 2021 May : Dutta, Suman et al. “α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy.” Acta neuropathologica 142,3 (2021): 495-511. MSA Coalition Grant #2017-10-007 (Bitan) BIOMARKER

  10. 2021 April : Miki Y, Tsushima E, Foti SC, Strand KM, Asi YT, Yamamoto AK, Hoskote C, Bettencourt C, Oliveira MCB, De Pablo-Fernández E, Jaunmuktane Z, Lees AJ, Wakabayashi K, Warner TT, Quinn N, Holton JL, Ling H (2021). Identification of multiple system atrophy mimicking Parkinson’s disease or progressive supranuclear palsy. Brain 144(4):1138-1151. MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS

  11. 2021 Apr: Palma, Jose-Alberto et al. “Limitations of the Unified Multiple System Atrophy Rating Scale as outcome measure for clinical trials and a roadmap for improvement.Clinical autonomic research : official journal of the Clinical Autonomic Research Society vol. 31,2 (2021): 157-164.

  12. 2021 Feb : Shadrin, Alexey A et al. “Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease.” Movement disorders : official journal of the Movement Disorder Society, 36,2 (2021): 449-459. MSA Coalition Grant #2017-10-006 (Sharma) PATHOGENESIS

  13. 2021 Jan : Krismer, Florian et al. “Automated Analysis of Diffusion-Weighted Magnetic Resonance Imaging for the Differential Diagnosis of Multiple System Atrophy from Parkinson’s Disease.” Movement disorders : official journal of the Movement Disorder Society 36,1 (2021): 241-245. MSA Coalition Grant #2015-04-003 (Krismer) BIOMARKER

  14. 2021 Jan : Marmion, David J et al. “Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.” Neurobiology of disease 148 (2021): 105184. MSA Coalition Grant #2017-10-002 (Kordower) PATHOGENESIS

    (2015 –2020)

  15. 2020 Nov : Raccagni, Cecilia et al. “Gait and postural disorders in parkinsonism: a clinical approach.” Journal of neurology 267,11 (2020): 3169-3176. MSA Coalition Grant #2016-09-008 (Wenning) BIOMARKER
  16. 2020 Jul : Lopez-Cuina, Miguel et al. “Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy.” Movement disorders : official journal of the Movement Disorder Society 35,7 (2020): 1163-1172. MSA Coalition Grant #2016-09-010 (Fernagut) PRECLINICAL
  17. 2020 Jun : Piras, Ignazio S et al. “Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease.” Acta neuropathologica communications 8,1 76. 3 Jun. 2020, MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS
  18. 2020 Jun : Palma, Jose-Alberto et al. “The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension.” Parkinsonism & related disorders 75 (2020): 97-104.
  19. 2020 May : Ruf, Viktoria C et al. “Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC.” FEBS open bio 10,5 (2020): 883-893. MSA Coalition Grant #2015-04-005 (Giese) BIOMARKER
  20. 2020 May : Bettencourt, Conceição et al. “Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis.” Acta neuropathologica communications 8,1 71. 14 May. 2020, MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS
  21. 2020 Mar : Vidal-Martinez, Guadalupe et al. “FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models.” Experimental neurology 325 (2020): 113120. MSA Coalition Grant #2015-04-009 (Perez) PRECLINICAL
  22. 2020 Jan : Bettencourt, Conceição et al. “White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy.” Acta neuropathologica 139,1 (2020): 135-156. MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS
  23. 2020 Jan : Vidal-Martinez, Guadalupe et al. “A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models.” Journal of Parkinson’s disease 10,1 (2020): 185-192. MSA Coalition Grant #2015-04-009 (Perez) PRECLINICAL
  24. 2019 Nov : Herrera-Vaquero, Marcos et al. “The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.” Biochimica et biophysica acta. Molecular basis of disease 1865,11 (2019): 165513. MSA Coalition Grant #2015-04-006 (Stefanova) PRECLINICAL
    MSA Coalition Grant #2016-09-005 (Stefanova) PRECLINICAL
  25. 2019 Oct : Raccagni, C et al. “Physiotherapy improves motor function in patients with the Parkinson variant of multiple system atrophy: A prospective trial.” Parkinsonism & related disorders 67 (2019): 60-65. MSA Coalition Grant #2016-09-008 (Wenning) BIOMARKER
  26. 2019 Oct : Cortelli, Pietro et al. “Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment.” Neurology 93,14 (2019): 630-639. MSA Coalition Participated at the 2017 Consensus Conference in Bologna, Italy.
  27. 2019 Sep : Folke, Jonas et al. “Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease.” Frontiers in immunology 10 2253. 24 Sep. 2019, doi:10.3389/fimmu.2019.02253 MSA Coalition Grant #2017-10-008 (Pakkenberg) PATHOGENESIS
  28. 2019 Sep : Mavroeidi, Panagiota et al. “Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.” Acta neuropathologica 138,3 (2019): 415-441. MSA Coalition Grant #2016-09-003 (Xilouri) PATHOGENESIS
  29. 2019 Jul: Stankovic, Iva et al. “A critique of the second consensus criteria for multiple system atrophy.” Movement disorders : official journal of the Movement Disorder Society 34,7 (2019): 975-984. MSA Coalition Participated at the 2018 Diagnostic Criteria Meeting in New York City, USA.
  30. 2019 Jul : Krismer, Florian et al. “Morphometric MRI profiles of multiple system atrophy variants and implications for differential diagnosis.” Movement disorders : official journal of the Movement Disorder Society 34,7 (2019): 1041-1048. MSA Coalition Grant #2015-04-003 (Krismer) BIOMARKER
  31. 2019 Apr : Vallelunga, Annamaria et al. “Serum miR-30c-5p is a potential biomarker for multiple system atrophy.” Molecular biology reports 46,2 (2019): 1661-1666. MSA Coalition Grant #2016-09-007 (Vallelunga) BIOMARKER
  32. 2019 Apr : Kishore, Asha et al. “Understanding the role of genetic variability in LRRK2 in Indian population.” Movement disorders : official journal of the Movement Disorder Society 34,4 (2019): 496-505. MSA Coalition Grant #2017-10-006 (Sharma) PATHOGENESIS
  33. 2019 Jan : Gaßner, Heiko et al. “The Diagnostic Scope of Sensor-Based Gait Analysis in Atypical Parkinsonism: Further Observations.” Frontiers in neurology 10 5. 22 Jan. 2019, MSA Coalition Grant #2016-09-008 (Wenning) BIOMARKER
  34. 2019 Jan : Kiely, A P et al. “Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy.” Neuropathology and applied neurobiology 45,4 (2019): 347-360. MSA Coalition Grant #2015-04-010 (Holton) PATHOGENESIS
  35. 2018 Sep : Mueller, Christoph et al. “The diagnostic accuracy of the hummingbird and morning glory sign in patients with neurodegenerative parkinsonism.” Parkinsonism & related disorders 54 (2018): 90-94. MSA Coalition Grant #2015-04-003 (Krismer) BIOMARKER
  36. 2018 Aug : Krismer, Florian et al. “Abnormalities on structural MRI associate with faster disease progression in multiple system atrophy.” Parkinsonism & related disorders 58 (2019): 23-27. MSA Coalition Grant #2015-04-003 (Krismer) BIOMARKER
  37. 2018 Jun : Curry-Hyde, Ashton et al. “Multiple System Atrophy: Many Lessons from the Transcriptome.” The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 24,3 (2018): 294-307. MSA Coalition Grant #2016-09-002 (Janitz) PATHOGENESIS
  38. 2018 Jun : Raccagni, Cecilia et al. “Sensor-based gait analysis in atypical parkinsonian disorders.” Brain and behavior 8,6 (2018): e00977. MSA Coalition Grant #2016-09-008 (Wenning) BIOMARKER
  39. 2018 May : Bower, Pamela G. “Multiple system atrophy: Building a global community – 30years of advocacy efforts.” Autonomic neuroscience : basic & clinical 211 (2018): 39-42. A History of Accomplishments of the Multiple System Atrophy Coalition and Other Global Advocates.
  40. 2018 May : Peng, Chao et al. “Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.” Nature 557,7706 (2018): 558-563. MSA Coalition Grant #2017-10-003 (Peng) PATHOGENESIS
  41. 2018 Jan : Walsh, Ryan R et al. “Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.” Neurology 90,2 (2018): 74-82. MSA Coalition Participated at the 2014 Global Research Roadmap Meeting in Las Vegas, USA.
  42. 2018 Jan : Mangesius, Stephanie et al. “MR planimetry in neurodegenerative parkinsonism yields high diagnostic accuracy for PSP.” Parkinsonism & related disorders 46 (2018): 47-55. MSA Coalition Grant #2015-04-003 (Krismer) BIOMARKER
  43. 2017 Dec : Bajaj, Sweta et al. “Diffusion-weighted MRI distinguishes Parkinson disease from the parkinsonian variant of multiple system atrophy: A systematic review and meta-analysis.” PloS one 12,12 e0189897. 29 Dec. 2017 MSA Coalition Grant #2015-04-003 (Krismer) BIOMARKER
  44. 2017 Nov : Whittaker, Heather T et al. “Multiple system atrophy: genetic risks and alpha-synuclein mutations.” F1000Research 6 2072. 30 Nov. 2017 MSA Coalition Grant #2015-04-002 (Houlden) PATHOGENESIS
  45. 2017 Jun : Brettschneider, J et al. “Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type.” Neuropathology and applied neurobiology 43,4 (2017): 315-329. MSA Coalition Grant #2014-04-001 (Brettschneider) PATHOGENESIS
  46. 2017 May : Bassil, Fares et al. “Insulin resistance and exendin-4 treatment for multiple system atrophy.” Brain : a journal of neurology 140,5 (2017): 1420-1436. MSA Coalition Grant #2015-04-008 (Meissner) PRECLINICAL
  47. 2017 Feb : Khurana, Vikram et al. “Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.” Cell systems 4,2 (2017): 157-170.e14. MSA Coalition Grant #2013-12-002 (Khurana) PATHOGENESIS
  48. 2017 Feb : Chung, Chee Yeun et al. “In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.” Cell systems 4,2 (2017): 242-250.e4. MSA Coalition Grant #2013-12-002 (Khurana) PATHOGENESIS
  49. 2017 Jan : Valera, Elvira et al. “Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.” Acta neuropathologica communications 5,1 2. 5 Jan. 2017 MSA Coalition Grant #2015-04-004 (Masliah) PRECLINICAL
  50. 2016 Dec : Coon, Elizabeth A et al. “Medullary neuronal loss is not associated with α-synuclein burden in multiple system atrophy.” Movement disorders : official journal of the Movement Disorder Society 31,12 (2016): 1802-1809. MSA Coalition Grant #2013-12-003 (Benarroch) PATHOGENESIS
  51. 2016 Sep : Vidal-Martínez, Guadalupe et al. “FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.” The Journal of biological chemistry 291,39 (2016): 20811-21. MSA Coalition Grant #2015-04-009 (Perez) PRECLINICAL
  52. 2015 Sep : Spencer, Brian et al. “A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.” Molecular neurodegeneration 10 48. 23 Sep. 2015 MSA Coalition Grant #2013-12-004 (Masliah) PRECLINICAL
  53. 2015 Aug : Cykowski, Matthew D et al. “Expanding the spectrum of neuronal pathology in multiple system atrophy.” Brain : a journal of neurology 138,Pt 8 (2015): 2293-309. MSA Coalition Grant #2015-04-007 (Benarroch) PATHOGENESIS
  54. 2015 Jul : Benarroch, Eduardo E et al. “Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies.” Movement disorders : official journal of the Movement Disorder Society 30,8 (2015): 1133-9. MSA Coalition Grant #2014-04-002 (Benarroch) PATHOGENESIS
  55. 2015 Feb : Norcliffe-Kaufmann, Lucy et al. “Multiple system atrophy: the case for an international collaborative effort.” Clinical autonomic research : official journal of the Clinical Autonomic Research Society 25,1 (2015): 81-3. MSA Coalition Grant #2013-12-001 (Norcliffe-Kaufmann/Krismer) CLINICAL

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