Peer Reviewed Articles

All of the below articles have recognized the support of the MSA Coalition.




Calandra-Buonaura, Giovanna et al. “Dysphagia in multiple system atrophy consensus statement on diagnosis, prognosis and treatment.” Parkinsonism & related disorders, S1353-8020(21)00120-6. 30 Mar. 2021,

Palma, Jose-Alberto et al. “Limitations of the Unified Multiple System Atrophy Rating Scale as outcome measure for clinical trials and a roadmap for improvement.Clinical autonomic research : official journal of the Clinical Autonomic Research Society vol. 31,2 (2021): 157-164.


Mov Disord. 2020 Apr 14.
Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy. Lopez-Cuina M, Guerin PA, Canron MH, Delamarre A, Dehay B, Bezard E, Meissner WG, Fernagut PO.

FEBS Open Bio 2020 May;10(5):883-893.
Potential sources of interference with the highly sensitive detection and quantification of alpha-synuclein seeds by qRT-QuIC
Viktoria C Ruf, Song Shi, Felix Schmidt, Daniel Weckbecker, Georg S Nübling, Uwe Ködel, Brit Mollenhauer, Armin Giese

Parkinsonism Relat Disord 2020 Jun;75:97-104.
The impact of supine hypertension on target organ damage and survival in patients with synucleinopathies and neurogenic orthostatic hypotension
Jose-Alberto Palma, Gabriel Redel-Traub, Angelo Porciuncula, Daniela Samaniego-Toro, Patricio Millar Vernetti, Yvonne W Lui, Lucy Norcliffe-Kaufmann, Horacio Kaufmann

Mov Disord. 2020 Sep 16.
Automated Analysis of Diffusion‐Weighted Magnetic Resonance Imaging for the Differential Diagnosis of Multiple System Atrophy from Parkinson’s Disease.
Florian Krismer, Vincent Beliveau, Klaus Seppi, Christoph Mueller, Georg Goebel, Elke R Gizewski, Gregor K Wenning, Werner Poewe, Christoph Scherfler

Mov Disord. 2020 Oct 27
Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease
Alexey A. Shadrin PhD Sören Mucha PhD David Ellinghaus PhD Mary B. Makarious BSc Cornelis Blauwendraat PhD Ashwin A.K. Sreelatha MSc Antonio Heras‐Garvin PhD Jinhui Ding PhD Monia Hammer PhD Alexandra Foubert‐Samier MD Wassilios G. Meissner MD Olivier Rascol PhD Anne Pavy‐Le Traon MD Oleksandr Frei PhD Kevin S. O’Connell PhD Shahram Bahrami PhD Stefan Schreiber MD Wolfgang Lieb MD Martina Müller‐Nurasyid PhD Ulf Schminke MD Georg Homuth PhD Carsten O. Schmidt PhD Markus M. Nöthen MD Per Hoffmann PhD Christian Gieger PhD Gregor Wenning MD for the European Multiple System Atrophy Study Group J. Raphael Gibbs PhD Andre Franke PhD John Hardy PhD Nadia Stefanova PhD Thomas Gasser MD Andrew Singleton PhD Henry Houlden MD Sonja W. Scholz MD Ole A. Andreassen PhD Manu Sharma PhD

Neurobiol Dis. 2020 Nov 19;148:105184.
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease
David J Marmion, Angela A Rutkowski, Diptaman Chatterjee, Benjamin M Hiller, Milton H Werner, Erwan Bezard, Deniz Kirik, Thomas McCown, Steven J Gray, Jeffrey H Kordower

J Neurol. 2020 Dec 31.

Characterization of gait variability in multiple system atrophy and Parkinson’s disease
Victoria Sidoroff, Cecilia Raccagni, Christine Kaindlstorfer, Sabine Eschlboeck, Alessandra Fanciulli, Roberta Granata, Björn Eskofier, Klaus Seppi, Werner Poewe, Johann Willeit, Stefan Kiechl, Philipp Mahlknecht, Heike Stockner, Kathrin Marini, Oliver Schorr, Gregorio Rungger, Jochen Klucken, Gregor Wenning, Heiko Gaßner


Front Neurol. 2019 Jan 22;10:5.
The Diagnostic Scope of Sensor-Based Gait Analysis in Atypical Parkinsonism: Further Observations.
Gaßner H, Raccagni C, Eskofier BM, Klucken J, Wenning GK.

Mov Disord. 2019 Mar 28.
Morphometric MRI profiles of multiple system atrophy variants and implications for differential diagnosis.
Krismer F, Seppi K, Göbel G, Steiger R, Zucal I, Boesch S, Gizewski ER, Wenning GK, Poewe W, Scherfler C

Mol Biol Rep. 2019 Apr;46(2):1661-1666.
Serum miR-30c-5p is a potential biomarker for multiple system atrophy.
Vallalunga A, Iannitti T, Dati G, Capece S, Maugeri M, Tocci E, Picillo M, Volpe G, Cozzolino A, Squillante M, Cicarelli G, Barone P, Pellecchia MT.

Acta Neuropathol. 2019 Apr 22.
Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.
Mavroeidi P, Arvanitaki F, Karakitsou AK, Vetsi M, Kloukina I, Zweckstetter M, Giller K, Becker S, Sorrentino ZA, Giasson BI, Jensen PH, Stefanis L, Xilouri M.

2019 Jul 15. pii: S0925-4439(19)30230-3.
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.
Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N.

2019 Sep 24;67:60-65.

Physiotherapy improves motor function in patients with the Parkinson variant of multiple system atrophy: A prospective trial.
Raccagni C, Goebel G, Gaßner H, Granata R, Ndayisaba JP, Seebacher B, Schoenherr G, Mitterhuber J, Hendriks P, Kaindlstorfer C, Eschlboeck S, Fanciulli A, Krismer F, Seppi K, Poewe W, Bloem BR, Klucken J, Wenning GK.

Neurology. 2019 Oct 1;93(14):630-639.
Stridor in multiple system atrophy: Consensus statement on diagnosis, prognosis, and treatment.
Cortelli P, Calandra-Buonaura G, Benarroch EE, Giannini G, Iranzo A, Low PA, Martinelli P, Provini F, Quinn N, Tolosa E, Wenning GK, Abbruzzese G, Bower P, Alfonsi E, Ghorayeb I, Ozawa T, Pacchetti C, Pozzi NG, Vicini C, Antonini A, Bhatia KP, Bonavita J, Kaufmann H, Pellecchia MT, Pizzorni N, Schindler A, Tison F, Vignatelli L, Meissner WG.

2019 Oct 31.
Association of innervation-adjusted alpha-synuclein in arrector pili muscles with cardiac noradrenergic deficiency in autonomic synucleinopathies.
Isonaka R, Gibbons CH, Wang N, Freeman R, Goldstein DS.


Neurology. 2018 Jan 9; 90(2): 74–82.
Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.
Walsh RR, Krismer F, et al

Parkinsonism Relat Disord. 2018 Jan;46:47-55.
MR planimetry in neurodegenerative parkinsonism yields high diagnostic accuracy for PSP.
Mangesius S, Hussl A, Krismer F, Mahlknecht P, Reiter E, Tagwercher S, Djamshidian A, Schocke M, Esterhammer R, Wenning G, Müller C, Scherfler C, Gizewski ER, Poewe W, Seppi K.

Auton Neurosci. 2018 May;211:39-42.
Multiple system atrophy: Building a global community – 30years of advocacy efforts.
Bower PG.

Nature. 2018 May;557(7706):558-563.
Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.
Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM.

Brain Behav. 2018 Jun;8(6):e00977.
Sensor-based gait analysis in atypical parkinsonian disorders.
Raccagni C, Gaßner H, Eschlboeck S, Boesch S, Krismer F, Seppi K, Poewe W, Eskofier BM, Winkler J, Wenning G, Klucken J.

Neuropathol Appl Neurobiol. 2018 Jul 11.
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy.
Kiely AP, Miners S, Courtney R, Strand C, Love S, Holton JL.

2018 Sep;54:90-94.

The diagnostic accuracy of the hummingbird and morning glory sign in patients with neurodegenerative parkinsonism.
Mueller C, Hussl A, Krismer F, Heim B, Mahlknecht P, Nocker M, Scherfler C, Mair K, Esterhammer R, Schocke M, Wenning GK, Poewe W, Seppi K


Acta Neuropathol Commun. 2017 Jan 5;5(1):2. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy
Elvira Valera, Brian Spencer, Jerel A. Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats and Eliezer Masliah

Cell Syst. 2017 Feb 22;4(2):157-170.e14.
Genome-scale networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways
Vikram Khurana, Jian Peng, Chee Yeun Chung, et al

Cell Syst. 2017 Feb 22;4(2):242-250.e4.
In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.
Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S.

Brain. 2017 May 1;140(5):1420-1436.
Insulin resistance and exendin-4 treatment for multiple system atrophy
Fares Bassil, Marie-Hélène Canron, Anne Vital, Erwan Bezard, Yazhou Li, Nigel H Greig, Seema Gulyani, Dimitrios Kapogiannis, Pierre-Olivier Fernagut, Wassilios G Meissner

Neuropathol Appl Neurobiol. 2017 Jun;43(4):315-329.
Progression of alpha‐synuclein pathology in multiple system atrophy of the cerebellar type
J. Brettschneider, D. J. Irwin, S. Boluda, M. D. Byrne, L. Fang, E. B. Lee, J. L. Robinson, E. Suh, V. M. Van Deerlin, J. B. Toledo, M. Grossman, H. Hurtig, R. Dengler, S. Petr, V. M.‐Y. Lee, J. Q. Trojanowski

F1000Res. 2017 Nov 30;6:2072.
Multiple system atrophy: genetic risks and alpha-synuclein mutations.
Whittaker HT, Qui Y, Bettencourt C, Houlden H

PLoS One. 2017 Dec 29;12(12):e0189897.
Diffusion-weighted MRI distinguishes Parkinson disease from the parkinsonian variant of multiple system atrophy: A systematic review and meta-analysis
Sweta Bajaj, Florian Krismer, Jose-Alberto Palma, Gregor K. Wenning, Horacio Kaufmann, Werner Poewe, Klaus Seppi


J Biol Chem. 2016 Sep 23;291(39):20811-21.
FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF*
Guadalupe Vidal-Martínez, Javier Vargas-Medrano, Carolina Gil-Tommee, David Medina, Nathan T. Garza, Barbara Yang, Ismael Segura-Ulate, Samantha J. Dominguez, and Ruth G. Perez

Mov Disord. 2016 Dec;31(12):1802-1809.
Medullary neuronal loss is not associated with α‐synuclein burden in multiple system atrophy
Elizabeth A. Coon, Ann M. Schmeichel, AS Joseph, E. Parisi MD, Matthew D. Cykowski MD, Phillip A. Low MD, Eduardo E. Benarroch MD


Clin Auton Res. 2015 Feb;25(1):81-3.
Multiple system atrophy: the case for an international collaborative effort.
Norcliffe-Kaufmann L, Palma JA, Krismer F.

Mov Disord. 2015 Jul;30(8):1133-9.
Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies
Eduardo E. Benarroch MD, Ann M. Schmeiche, AS Joseph,E. Parisi MD, Phillip A. Low MD

Brain. 2015 Aug;138(Pt 8):2293-309.
Expanding the spectrum of neuronal pathology in multiple system atrophy.
Cykowski MD, Coon EA, Powell SZ, Jenkins SM, Benarroch EE, Low PA, Schmeichel AM, Parisi JE.

Mol Neurodegener. 2015 Sep 23;10:48.
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
Brian Spencer, Elvira Valera, Edward Rockenstein, Margarita Trejo-Morales, Anthony Adame, and Eliezer Masliah